Since carbidopa prevents the reversal of levodopa effects caused by pyridoxine, sinemet cr can be given to patients receiving supplemental pyridoxine vitamin b 6 .
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if the patient anticipates disconnecting the pump for a short period of time less than 2 hours such as to swim, shower, or short medical procedure , no supplemental oral medication is needed, but the patient may be advised to take an extra-dose of sinemet retard before disconnecting.
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