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Taking estrogen-containing oral contraceptives in women not taking carbamazepine, phenytoin, phenobarbital, primidone, or other drugs such as rifampin and the protease inhibitors lopinavir ritonavir and atazanavir ritonavir that induce lamotrigine glucuronidation see drug interactions , clinical pharmacology , the maintenance dose of lamictal xr will in most cases need to be increased by as much as 2-fold over the recommended target maintenance dose to maintain a consistent lamotrigine plasma level.
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