Sulfamethoxazole; trimethoprim, smx-tmp, cotrimoxazole major because both trimethoprim and digoxin undergo tubular secretion, trimethoprim can interfere with the renal tubular secretion of digoxin when administered concomitantly.
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Patterns of susceptibility to antibiotics vary between countries, although high rates of in vitro resistance to ampicillin and cotrimoxazole, as reported in several african countries, are causing general concern.
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