Cost-effectiveness analysis of genotyping for hla-b 5801 and an enhanced safety program in gout patients starting allopurinol in singapore.
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A few cases of reversible clinical hepatotoxicity have been noted in patients taking allopurinol, and in some patients, asymptomatic rises in serum alkaline phosphatase or serum transaminase have been observed.
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The suppression has occurred from as early as 6 weeks to as long as 6 years after the initiation of allopurinol therapy.
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