Moderate concurrent administration of darunavir and indinavir results in increased darunavir and indinavir concentrations.
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in comparative clinical studies, there was at least a trend towards a lower incidence of serious adverse events with indinavir-containing regimens than with ritonavir-containing regimens.
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coadministration of conivaptan with ketoconazole, a potent cyp3a4 inhibitor, results in 4- and 11- fold increase in conivaptan cmax and auc, respectively; similar pharmacokinetic effects could be seen with the coadministration of conivaptan and indinavir.
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