Minor but common side effects of metformin include gastrointestinal disturbances such as diarrhea, nausea, and abdominal cramping.
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if metformin-associated lactic acidosis is suspected, immediately discontinue janumet xr and institute general supportive measures in a hospital setting.
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metformin participants in the low adherence group lost weight but placebo participants with low adherence did not.
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metformin alone was not teratogenic in rats or rabbits at doses up to 600 mg kg day.
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there was no clear evidence that metformin improved either rfs hr 0.
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These results indicate that the metformin-dependent inhibition of complex i decreases cell proliferation in the presence of glucose and increases cell death under glucose deprivation.
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