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distribution approximately 90 of circulating propranolol is bound to plasma proteins albumin and alpha 1 acid glycoprotein .
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a decrease in metoprolol and propranolol clearance has been observed when either drug is administered concomitantly with verapamil.
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propranolol should be administered with caution in this setting since it may provoke a bronchial asthmatic attack by blocking bronchodilation produced by endogenous and exogenous catecholamine stimulation of betareceptors.
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In a study conducted in 7 patients with cirrhosis and 9 healthy subjects receiving 80-mg oral propranolol every 8 hours for 7 doses, the steady-state unbound propranolol concentration in patients with cirrhosis was 3-fold that of controls.
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