The suppression has occurred from as early as 6 weeks to as long as 6 years after the initiation of allopurinol therapy.
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the concomitant administration of uricosuric agents and allopurinol has been associated with a decrease in the excretion of oxypurines hypoxanthine and xanthine and an increase in urinary uric acid excretion compared with that observed with allopurinol alone.
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in transferring a patient from a uricosuric agent to allopurinol, the dose of the uricosuric agent should be gradually reduced over a period of several weeks and the dose of allopurinol gradually increased to the required dose needed to maintain a normal serum uric acid level.
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the half-life of the drug is short 30 to 100 min with rapid conversion of allopurinol to oxipurinol.
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