A few cases of reversible clinical hepatotoxicity have been noted in patients taking allopurinol, and in some patients, asymptomatic rises in serum alkaline phosphatase or serum transaminase have been observed.
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pubmed 20046204 pacher p, nivorozhkin a, szabo c therapeutic effects of xanthine oxidase inhibitors renaissance half a century after the discovery of allopurinol.
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musculoskeletal and connective tissue disorders myopathy, rhabdomyolysis was reported and in some of the reports, clarithromycin was administered concomitantly with statins, fibrates, colchicine or allopurinol.
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Oral and intravenous administration of aloprim allopurinol sodium for injection at equal doses produced nearly superimposable oxypurinol plasma concentration vs time profiles, and the relative bioavailability of oxypurinol f relative was approximately 100 .
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