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dose appears to be an important predictor of seizure, with a greater likelihood of seizure at the higher clozaril doses used.
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fatal overdoses have been reported with clozaril, generally at doses above 2500 mg.
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although it is not known whether the risk would be increased, it is prudent either to avoid clozaril clozapine or use it cautiously in patients with a previous history of agranulocytosis induced by other drugs.
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orthostatic hypotension, bradycardia, syncope, and cardiac arrest have occurred with clozaril treatment.
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