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three patients developed druginduced hepatitis-all were taking isoniazid.
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corticosteroids, glucocorticoid and mineralocorticoid concurrent use with rifampin may enhance the metabolism of corticosteroids by induction of hepatic microsomal enzymes, resulting in a considerable decrease in corticosteroid plasma concentrations; dosage adjustment may be required; rifampin has also counteracted endogenous cortisol and produced acute adrenal insufficiency in patients with addison s disease ; concurrent use of prednisolone, and other related corticosteroids, with isoniazid may increase hepatic metabolism and or excretion of isoniazid, leading to decreased plasma concentrations and effectiveness of isoniazid, especially in patients who are rapid acetylators; isoniazid dosage adjustments may be required .
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