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specific guidelines for dosage adjustments in hepatic impairment are not available; however, ethionamide is contraindicated in patients with severe hepatic impairment see contraindications .
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isoniazid, inh; pyrazinamide, pza; rifampin moderate careful monitoring of hepatic function is recommended with the concurrent use of ethionamide and isoniazid, inh.
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To treat multidrug-resistant tuberculosis mdr-tb , the world health organization recommends to include, during the intensive phase of treatment, at least a parenteral agent, a later-generation fluoroquinolone, ethionamide eth or prothionamide pth , cycloserine cs or p -aminosalicylic acid pas if cs cannot be used, and pyrazinamide pzd which is not considered among the aforementioned four probably effective drugs 1, 2 .
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